“Keep it Simple,” Nobel Prize Winner Advises

English: Nobel laureate Dr. James D. Watson, C...
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I soon was taught that [Linus] Pauling’s accomplishment was a product of common sense, not the result of complicated mathematical reasoning. Equations occasionally crept into his argument, but in most cases words would have sufficed. The key to Linus’ success was his reliance on the simple laws of structural chemistry. The \alpha-helix had not been found by only staring at X-ray pictures; the essential trick, instead, was to ask which atoms like to sit next to each other. In place of pencil and paper, the main working tools were a set of molecular models superficially resembling the toys of preschool children.

We could thus see no reason why we should not solve DNA in the same way. All we had to do was to construct a set of molecular models and begin to play — with luck, the structure would be a helix. Any other type of configuration would be much more complicated. Worrying about complications before ruling out the possibility that the answer was simple would have been damned foolishness. Pauling never got anywhere by seeking out messes.

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